Quantification of Inter-Sample Differences in T-Cell Receptor Repertoires Using Sequence-Based Information
نویسندگان
چکیده
منابع مشابه
Quantification of Inter-Sample Differences in T-Cell Receptor Repertoires Using Sequence-Based Information
Inter-sample comparisons of T-cell receptor (TCR) repertoires are crucial for gaining a better understanding of the immunological states determined by different collections of T cells from different donor sites, cell types, and genetic and pathological backgrounds. For quantitative comparison, most previous studies utilized conventional methods in ecology, which focus on TCR sequences that over...
متن کاملQuantification of inter-sample differences in T cell receptor sequences
2 Inter-sample comparisons of the T cell receptor (TCR) repertoire are crucial for gaining a better 3 understanding into the immunological states determined by different collections of T cells from 4 different donor sites, cell types, and genetic and pathological backgrounds. As a theoretical 5 approach for the quantitative comparison, previous studies utilized the Poisson abundance models 6 an...
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Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data. Here we report VDJtools, a complementary software suite that solves a wide range of T cell receptor (TCR) repertoires post-analysis tasks, provides a detailed tabular output and publication-ready graphics, and is built on top of a flexi...
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The relationship between maternal and child immunity has been actively studied in the context of complications during pregnancy, autoimmune diseases, and haploidentical transplantation of hematopoietic stem cells and solid organs. Here, we have for the first time used high-throughput Illumina HiSeq sequencing to perform deep quantitative profiling of T cell receptor (TCR) repertoires for periph...
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OBJECTIVE Refractory coeliac disease (RCD) is a potentially hazardous complication of coeliac disease (CD). In contrast to RCD type I, RCD type II is a precursor entity of enteropathy-associated T-cell lymphoma (EATL), which is associated with clonally expanding T-cells that are also found in the sequentially developing EATL. Using high-throughput sequencing (HTS), we aimed to establish the sma...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2017
ISSN: 1664-3224
DOI: 10.3389/fimmu.2017.01500